DNA methylation, an epigenetic modification, is closely related to the gene expression and chromatin remodeling. The precise identification of cytosine methylation status in genome plays a critical role in research and clinical areas, especially in precise oncology. With the treatment of bisulfite or enzymes, the unmethylated cytosine can be converted to uracil, whereas the methylated cytosine remains unchanged. Afterwards, combined with high-throughput sequencing technology, the genomic methylation status can be analyzed massively with single nucleotide resolution. The introduction of targeted enrichment technology can reduce the sequencing cost and improve the targeted analysis efficiency by improving the sequencing depth of interested regions. We offer an NGS total solution for capture-based methylation sequencing (Methyl-Seq) on both MGI sequencing platforms and Illumina sequencing platforms, including Methyl-Seq library preparation kit based on bisulfite or enzymatic conversion, design & synthesis service of capture probes, hybridization reagents related and integrated analysis tools.